- See:
-
wound management;
-
pressure irrigation;
- Discussion:
-
skin prep agents:
-
iodophors;
-
chlorohexidine;
- topical agents administered should be effective against Pen-Res
Staph
aureus and epidermidis, as well, as gram neg (
E.coli,
Klebsiella),
and Proteus (gm neg accounting for upto 1/3 of total joint infections);
-
neomycin
-
bacitracin
- in concentrations as low as 50,000 units/L and polymyxin in concentrations as low as 50 mg/liter
sterilized all cultures but S.epidermidis and Proteus species; - use 50 units per ml;
-
triple ATB:
- lowest concentrations of a triple ATB solution that eradicated all organisms were 5% neomycin (5-10 mg/ml), bacitracin 25,000
units/liter, and polymyxin 25 mg/liter (0.05 mg per ml)
- these agents should be allowed to remain in the wound for atleast one minute before their removal;
-
mafenide acetate tested at a clinical concentration of 10% resulted in average cell survival of 73 % of the population.
Local tissue effects of wound disinfectants. Br:anemark PI. Acta Chirurgica Scandinavica - Supplementum. 357:166-76, 1966.
Tissue injury caused by wound disinfectants. Br:anemark PI. Ekholm R. Journal of Bone & Joint Surgery - American Volume. 49(1):48-62, 1967 Jan.
Disinfection of surgical wounds without inhibition of normal wound healing.
Cellular and bacterial toxicities of topical antimicrobials.
Topical antimicrobial toxicity.
Bactericidal and wound-healing properties of sodium hypochlorite solutions: the 1991 Lindberg Award.
Antiseptic effectiveness with fibroblast preservation.
Antiseptic toxicity in wounds healing by secondary intention.
The Cytotoxic Effects of Commonly Used Topical Antimicrobial Agents on Human Fibroblasts and Keratinocytes.
In Vitro Toxicity Testing for Antibacterials Against Human Keratinocytes.
Comparison of bactericidal activities of various disinfectants against methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus.
Selection of topical antimicrobial agents for cultured skin for burns by combined assessment of cellular cytotoxicity and antimicrobial activity.
Comparison of silver sulphadiazine 1 per cent, silver sulphadiazine 1 % plus chlorhexidine digluconate 0.2 per cent and mafenide acetate 8.5 per cent for topical antibacterial effect in infected full skin thickness rat burn wounds.
Comparison of silver sulfadiazine 1% with chlorhexidine digluconate 0.2% to silver sulfadiazine 1% alone in the prophylactic topical antibacterial treatment of burns.
Cytotoxicity to cultured human keratinocytes of topical antimicrobial agents.
Studies in management of the contaminated wound. I. Technique of closure of such wounds together with a note on a reproducible experimental model.
Edlich RF. Tsung MS. Rogers W. Rogers P. Wangensteen OH. Journal of Surgical Research. [JC:k7b 8(12):585-92, 1968 Dec.
Evaluation of protocol change in burn-care management using the Cox proportional hazards model with time-dependent covariates.
Acceleration of wound healing by topical application of honey. An animal model.
Successful treatment of chronically infected wounds with sugar paste. x
Studies in management of the contaminated wound. 3. Assessment of the effectiveness of irrigation with antiseptic agents.
Studies in the management of the contaminated wound. V. An assessment of the effectiveness of pHisoHex and Betadine surgical scrub solutions.
Studies in the management of the contaminated wound. 8. Assessment of tissue adhesives for repair of contaminated tissue.
Edlich RF. Prusak M. Panek P. Madden J. Wangensteen OH. Thul J. American Journal of Surgery. [JC:3z4 122(3):394-7, 1971 Sep.
Air Embolism Associated with Irrigation of External Fixator Pin Sites with Hydrogen Peroxide. A Report of Two Cases.
