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Wheeless' Textbook of Orthopaedics

Septic Arthritis: Differential Diagnosis



- Diff Dx:
    - reactive transient synovitis (toxic synovitis)
            - in the report by MS Kocher et al., the authors sought to distinguish transient synovitis vs sepsis on the basis of lab data and patient history;
                  - independent clinical predictors between septic arthritis and transient synovitis included history of fever, non-wt-bearing,
                        ESR of at least forty mm/hr, and serum WBC of more than 12,000;
                  - the predicted probability for septic arthritis were 93% if three of these variables were present and were over 99% if all 4 predictors were present;
                  - the authors recommend careful observation without aspiration if none of the four independent predictors are present;
            - reference:
                  - Differentiating Between Septic Arthritis and Transient Synovitis of the Hip in Children: An Evidence-Based Clinical Prediction Algorithm. MS Kocher MD.   JBJS. Vol 81-A. Dec 1999. p 1662.
                  - Legg-Calve-Perthes disease
    - slipped capital femoral epiphysis
            - psoas abscess:
                  - note that these patients will hold the hip in flexion and in internal rotation (which is also seen in septic arthritis of the hip);
                  - look for atypical features, such as femoral nerve neurapraxia or bladder irritability along with hip pain;
                  - references:
                          - Psoas abscess in children.   SD Schwaitzberg.   J. Pediatric Surgery. Vol 20. 1985. 339-342.
                          - Differentiation of Psoas Muscle Abscess From Septic Arthritis of the Hip in Children.   John Song, MD. CORR 2001;2001:258-265
            - obturator internus pyomyositis:
                  - patients may demonstrate rectal pain and swelling during an examination;
                  - in the report by Shari L. Orlicek, M.D. et al, the authors describe 4 cases of obturator internus muscle (OIM) abscess in children,
                          including their clinical presentations and treatment;
                          - common presenting features were fever, limp, and hip pain;
                          - CT or MRI was diagnostic in all 4 patients, and staph aureus was the causative agent in each;
                          - all the patients recovered, one after surgical drainage and the other three after antimicrobial therapy alone or with needle aspiration;
                          - presentation of OIM pyomyositis is similar to that of psoas muscle pyomyositis and other infectious processes of the pelvis and hip;
                          - most patients can be managed without open surgical drainage, but needle aspirations may be helpful both therapeutically and diagnostically;
                  - references:
                        - Case Report.   Obturator Internus Pyomyositis.   M. Papadopoulos MD.   Orthopedics. Apr 2000. p 383.
                        - Obturator Internus Muscle Abscess in Children. Shari L. Orlicek, M.D. Journal of Pediatric Orthopaedics. 2001;21:744-748
            - acetabular osteomyelitis
            - pyogenic sacroiliitis
            - vertebral/disc space infections
            - proximal femoral osteomyelitis (see above)
            - sickle cell anemia;
            - juveline rheumatoid arthritis
            - neuroblastoma
                  - uncommon but should be considered in the differential diagnosis;
                  - abdominal ultrasonography may serve as a screening examination;









Suppurative arthritis of the hip in children.

Long-term follow-up of infantile hip sepsis.
    J Pediatr Orthop 1988;8:322-325. Wopperer JM, White JJ, Gillespie R, et al:

Sequelae and reconstruction after septic arthritis of the hip in infants.
    J Bone Joint Surg 1990;72A:1150-1165. Choi IH, Pizzutillo PD, Bowen JR, et al:

Evaluation of treatment modalities for septic arthritis with histologic grading and analysis of
    levels of uronic acid, neutral protease, and interleukin-1.
    KD Nord et al. JBJS Vol 77-A. p 258-265. 1995.

Acute hematogenous osteomyelitis and septic arthritis in childhood: A 10 year review and follow up. S Petersen et al.   Acta Orthop Scand. Vol 51: 1980. p 451-457.

Acute septic arthritis of the hip joint in infancy and childhood.

Pyogenic arthritis associated with adjacent osteomyelitis:   Identification of the sequelae prone child. MA Jackson et al.   Pediatric Infectious Disease Journal.   Vol 11. 1992. p 9-13;

The Role of Pelvic Magnetic Resonance in Evaluating Nonhip Sources of Infection in Children With Acute Nontraumatic Hip Pain.




















Original Text by Clifford R. Wheeless, III, MD.