- See:
-
Bld Prod Menu
-
Transfusion Therapy
- See:
Bleeding secondary to Platlet abnormalities:
- Discussion:
- volume: approximately 50 mL (60 x 10^9 platlets -? 1-5 x 10^11);
- one unit of platlet concentrate can raise the platlet count by 10,000;
- rate of infusion: as rapidly as possible; ? IV infusion over 30 min;
- indications: prevention or treatment of bleeding secondary to thrombocytopenia or platlet dysfunction;
- contraindications: TTP:
- usual order is 6-8 units (pooled);
- one unit of
platlets will increase platlet count by 1000; (check 1hr post platlet count);
- Complications:
-
alloimmunization: 75% of patients receiving platlets on a regular basis will become alloimmunized to platlet antigens
-
sepsis:
- platlets require storage at room temperature, which allows optimal situation for bacterial growth;
-
bleeding:
- hypothermia causes platlet dysfunction and increased bleeding time;
- w/ massive bleeding, must transfuse 8 units of
platlets for every 10-12 units of
pRBC's transfused;
- misc:
- Von Willebrand's dz: Treat with
cryoprecipitate or
DDAVP;
- acquired platlet dysfunction: w/ uremia try conjugated estrogens;
Hypothermia-induced reversible platelet dysfunction.
