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Wheeless' Textbook of Orthopaedics
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Pathogenesis of Legg Calve Perthes Disease





- Discussion:
      - following inital ischemic episode, most of the epiphysis is avascular;
      - while enchondral ossification temporaily halts, the articular cartilage, which
            is nourished by synovial fluid, continues to grow;
          - this results in widening of medial cartilage (joint) space & smaller
                  ossification center in involved hip;
      - revascularization occurs from periphery;
          - resumption of enchondral ossification within the epiphysis begins
                  peripherally and progresses centrally;
          - new bone is deposited on avascular bone, producing a net increase in
                  bone density;
      - in subchondral area, bone resorption exceeds new bone formation;
            - point is reached during resorption when subchondral area becomes
                  weak & is prone to collapse;



Original Text by Clifford R. Wheeless, III, MD.