- Discussion:
- see:
homeobox genes database
-
history: discovered by Marshall Urist in the early 1960's;
- currently sixteen different proteins (BMP-1 through BMP-16) have been identified;
- these proteins can now be produced by recombinant DNA technology and are further purified by column chromatography;
- proteins are a homodimer (2 subunits);
- osteoinduction is mediated by BMP-2 thru BMP-7 and BMP-9: these allow differentiation of mesenchymal stem cells into
osteoblasts;
- osteogenic proteins usually require
type I collagen as a carrier protein;
- ref:
Bone morphogenic protein and its application in trauma cases: A current concept update.
- Specific BMP Types:
-
BMP-2 (see:
infuse rhBMP-2 (medtronics))
- references:
-
Use of rhBMP-2 in Combination with Structural Cortical Allografts: Clinical and Radiographic Outcomes in Anterior Lumbar Spinal Surgery
-
The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2).
A radiographic, histological, and biomechanical study in rats.
-
Percutaneous Injection of Recombinant Human BMP-2 in a Calcium Phosphate Paste Accelerates Healing of a Canine Tibial Osteotomy.
-
Recombinant human bone morphogenic protein-2 in fracture care.
-
Recombinant Human Bone Morphogenetic Protein-2 in Open Tibial Fractures.
-
Recombinant Human BMP-2 in Open Tibial Fractures. A Subgroup Analysis of Data Combined from Two Prospective Randomized Studies.
-
Recombinant Human BMP-2 and Allograft Compared with Autogenous Bone Graft for Reconstruction of Diaphyseal Tibial Fractures with Cortical Defects
-
sigma aldrich
-
OP-1 (BMP-7) from Stryker
- references:
-
The Effect of Recombinant Human Osteogenic Protein-1 on Healing of Large Segmental Bone Defects.
-
Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates.
-
Application of recombinant BMP-7 on persistent upper and lower limb non-unions.
-
Recombinant human bone morphogenic protein-7: applications for clinical trauma.
-
Treatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human BMP-7 (rhBMP-7). A Report of 5 Cases.
-
RhBMP-7 accelerates the healing in distal tibial fractures treated by external fixation.
-
BMP's obtained from cadavera:
- in the study by Cunningham et al 1999, osteogenic proteins were equivalent to autogenous grafting for achieving interbody fusions;
- note: these proteins are fragile and care must be taken with sterilization techniques;
- sterilization via irradiation will dramatically decrease the effectiveness of BMPs;
- defatting via chloroform/ethanol and freezing to minus 70 deg appear to have little effect on BMP effectiveness;
- references:
-
The use of DBM in the repair of segmental defects. Augmentation with extracted matrix proteins and a comparison with autologous grafts.
-
Resistant nonunions and partial or complete segmental defects of long bones. Treatment with implants of a composite
of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogeneic (AAA) bone.
Porous hydroxyapatite as a bone-graft substitute in metaphyseal defects. A histometric study.
Recombinant human bone morphogenetic protein induces bone formation.
Enhancement of bone ingrowth by transforming growth factor-beta.
Bone formation by autoinduction. Urist, MR. Science. Vol 150. 1965. 893-899.
Osteogenic protein versus autologous interbody arthrodesis in the sheep thoracic spine. BW Cunningham et al. Spine Vol 24. No 6. p 509-518. March 1999.
rhBMP-2/Calcium Phosphate Matrix Accelerates Osteotomy-Site Healing in a Nonhuman Primate Model at Multiple Treatment Times and Concentrations.
The effect of osteogenin (a bone morphogenetic protein) on the formation of bone in orthotopic segmental defects in rats.
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