Growth plate physiology and pathology. [Review]
Iannotti JP. University of Pennsylvania School of Medicine, Philadelphia. Orthop Clin North Am. 21(1):1-17, 1990 Jan. The growth plate is made of cartilaginous, bony, and fibrous components, which act together to achieve longitudinal bone growth. The unique metabolism of the growth plate is a result of its unique microcirculation and extracellular microenvironment. The growth plate chondrocytes are responsive to both mechanical and hormonal stimuli, which can alter their normal function. Pathologic states result from environmental, hormonal, nutritional, and genetic factors. [References: 155]
Original Text by Clifford R. Wheeless, III, MD.
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