- Dosing Regimens for Patients w/ Renal Insufficiency:
(Dose for 70 kg Adult (gm/dosing interval in hours)
CrCl:>80: 0.1-0.2/24; CrCl: 50-79: 0.1-0.2/24; CrCl: 30-49: 0.05-0.1/24;
CrCl:10-29: 0.025-0.05/24;
- 80 % of dose will be excreted in urine (w/ nl R F(x))
- Will increase effect of warfarin;
- Will falsely incr Serum Cr;
- Ratio of CSF to Blood Level (%): Nl Meninges: 70-80; Inflammed: > 70-80;
Ref for Fluconazole:
Original Articles: A Randomized Trial Comparing Fluconazole With
Amphotericin B For The Treatment Of Candidemia In Patients Without
Neutropenia.
