- Hypersensitivity - Decrease dose with renal insufficiency - Interaction w/
Dicumarol (prolonged PT) - Thiazide diruretics (increased allopurinol toxicity) - Ampicillin/amoxicillin (skin rashes) - Chlorpropamide (increased hypoglycemia) - Cyclophosphamide and other cytotoxic agents (bone marrow suppression); - the allopurinol hypersensitivity syndrome is characterized by fever, eosinophilia, leukocytosis, impaired renal function, hepatocellular injury and rash; - these reactions are severe and may be fatal; - allopurinol should be used carefully with those w/ renal insufficiency, a h/o uric acid stones and those with a 24 hour urinary acid excretion over 1,100 mg;
