- Normal Values: Adult: 45-125 U/L, Child 20-150 U/L;
- Increased:
- increased calcium deposition in bone
-
hyperparathryroidism
-
pagets disease
-
osteomalacia /
rickets: in both cases there is failure of mineralization;
-
caffey's syndrome (infantile cortical hyperostosis)
- osteoblastic bone tumors (metastatic or osteogenic sarcoma)
- alk phos level is high in about 1/2 of pts w/
osteosarcoma & in smaller
fraction of those w/ another type of primary malignant bone tumor;
- pregnancy
- childhood
- liver dz such as biliary obstruction
- TPN
- Decreased:
- malnutrition
- excess Vit D ingestion;
-
hypophosphatasia
Plasma bone-specific alkaline phosphatase as an indicator of osteoblastic activity.
